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Research Article
Vaginal prostaglandin E2 versus oxytocin for induction of labor in women with prelabor rupture of membranes at term
1 Registrar in Obstetrics & Gynaecology, Colombo North Teaching Hospital, Ragama, Sri Lanka
2 Professor in Obstetrics & Gynaecology, Colombo North Teaching Hospital, Ragama, Sri Lanka
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DPL Rasanjana
526/3, Heenkenda, Ragama,
Sri Lanka
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Article ID: 100011M01DR2022
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Rasanjana DPL, Wijesinghe PS, Gunarathna SMSG, Rathnayaka NMNB. Vaginal prostaglandin E2 versus oxytocin for induction of labor in women with prelabor rupture of membranes at term. Edorium J Matern Child Health 2022;7(2):1–7.ABSTRACT
Aims: Majority of women with prelabor rupture of membranes (PROM) at term will go in to labor within 24 hours. However early delivery will reduce the maternal and fetal infection and reduce the need for antibiotics for newborn. It will also increase maternal satisfaction. Oxytocin is being used for several decades for induction of labor in PROM. Prostaglandin E2 (PGE2) has shown promising results for the same purpose. A randomized controlled trial carried out to determine the effectiveness and acceptability of vaginal prostaglandin E2 for induction of labor in women with PROM at term.
Methods: A total of 162 women with singleton pregnancies at >37 weeks, cephalic presentations, Bishop scores of <6 were randomly allocated to receive either oxytocin or vaginal PGE2. The primary outcome measure was induction to delivery interval. Secondary outcomes were caesarean section rate, postpartum maternal fever, neonatal fever, and special care baby unit (SCBU) admissions.
Results: The induction to delivery interval was not significantly different (p -0.558) in oxytocin group (630.9 + 31.1 min) as compared to PGE2 group (635.2 + 27.1 min). Incidence of postpartum maternal fever, neonatal fever, and SCBU admission were almost similar in both groups. Uncomplicated vaginal delivery rates 2022were almost same in both groups (65.3% in PG group and 62.5% in oxytocin group).
Conclusion: Vaginal PGE2 appears to be as efficient as oxytocin for labor induction in term pregnancies with PROM and unfavorable cervices. However PGE2 doesn’t have additional advantages over oxytocin. As vaginal PGE2 is more expensive, it is rational to opt for oxytocin infusion to induce labor in term prelabor rupture of membranes accompanied with low Bishop’s scores.
Keywords: Induction, Oxytocin, Prelabor rupture of membranes instead of PROM, Prostaglandin E2
SUPPORTING INFORMATION
Acknowledgments
We would like to thank all the patients who participated in this clinical trial and to all the people who supported us throughout the study.
Author ContributionsDPL Rasanjana - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
PS Wijesinghe - Substantial contributions to conception and design, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
SMSG Gunarathna - Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
NMNB Rathnayaka - Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 DPL Rasanjana et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
