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Original Article
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| Fetomaternal outcome in preeclampsia and eclampsia and its association with neutrophil gelatinase-associated lipocalin in North Indian population | ||||||
| Munna Lal Patel1, *Neha Negi2, Pushplata Sachan3, Rekha Sachan4, Radheyshyam5 | ||||||
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1MD, Associate Professor, Department of Medicine, King George Medical University, U.P. Lucknow.
2MD, Senior Resident, Department of Obstetrics &Gynaecology, King George Medical University, U.P., Lucknow. 3MD, Assistant Professor, Department of Physiology, Career Institute of medical Sciences, Lucknow. 2MS, FICOG, Professor, Department of Obstetrics & Gynaecology, King George Medical University, U. P. Lucknow. 3MD, Assistant Professor, Department of Geriatric Mental Health, King Georges' Medical University, Lucknow. | ||||||
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| Patel ML, Negi N, Sachan P, Sachan R, Radheyshyam. Fetomaternal outcome in preeclampsia and eclampsia and its association with neutrophil gelatinase-associated lipocalin in North Indian population. Edorium J Matern Child Health 2016;1:1–7. |
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Abstract
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Aims:
Hypertensive disorders of pregnancy (HDP) seriously endangers the safety of mother and fetus during pregnancy. The aim of this study was to evaluate the association of neutrophil gelatinase-associated lipocalin levels (NGAL) with feto-maternal outcome in hypertensive disorders of pregnancy.
Methods: Prospective case-control study was carried out for one year. After informed consent, ethical clearance, total 180 pregnant women at 28–40 weeks of gestation age were recruited, out of which seven were lost to follow-up. Out of the remaining 173 patients, 31 were taken as controls, 65 as mild preeclampsia, 32 as severe preeclampsia and 45 as eclampsia. Estimation of serum neutrophil gelatinase- associated lipocalin was done by the enzyme linked immunosorbent assay (ELISA) technique, by using sandwich ELISA kit. Results: Negative correlation was observed between NGAL value with baby weight, maternal complication and neonatal death. Babies with low (2–2.5 kg) and very low (<2.0 kg) birth weight had significantly high NGAL levels compared to adequate for gestational age (term) babies (>2.5 kg), p-value < 0.001. The odds of resuscitation required were 2.69 times in birth weight group of 2.0–2.5 kg and with birth weight > 2.5 kg odds of resuscitations were 1.43 times. The odds of 5.84 times higher with admission to NICU in birth weight group of 2.0–2.5 kg as compared to birth weight > 2.5 kg (1.65 times). Conclusion: NGAL may also be an indicator for adverse maternal and neonatal outcomes. | |
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Keywords:
Fetal outcome, Hypertensive disorders of pregnancy, Maternal outcome, Neutrophil gelatinase-associated lipocalin (NGAL)
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Author Contributions:
Munna Lal Patel – Substantial contributions to conception and design, Acquisition of data, Analysis and interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published Neha Negi – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Pushplata Sachan – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Rekha Sachan – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published Radheyshyam – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published |
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Guarantor of submission
The corresponding author is the guarantor of submission. |
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Source of support
None |
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Conflict of interest
Authors declare no conflict of interest. |
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Copyright
© 2016 Munna Lal Patel et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information. |
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